Even worse for Howard, Bernadette's accomplishment leads to her getting a very lucrative job. All of the sudden, her career is more important and profitable than Howard's. Her buying him a Rolex watch only humiliates him more, feeling like he isn't providing for his lady, something he wants to do. It is no wonder they soon have a fight, and Howard has to seek comfort in his friends.
In all likelihood, Howard and Bernadette will be able to move past these developments. They have a deep affection for each other, and while Howard can be insecure, he tries really hard not to be, and usually eventually overcomes those insecurities. This is a rough patch, to be sure, but not an insurmountable one. Perhaps some positive will even come of it, if it spurs Howard to get his own PhD. This will not stop the wedding by any means.
Is there any way Howard and Bernadette can have a wedding and Howard's mother will still not be shown on screen? Sure, the director can get creative with camera angles and objects blocking her, but why go to the trouble? It may finally be time for a Mrs. Wolowitz reveal.
The Big Bang Theory has been renewed, and will return to CBS in the fall.