Numb is a low budget movie with a surprising cast of stars, including Matthew Perry in the lead and Kevin Pollak and Mary Steenburgen co-starring. The cast is surprising because it is a Canadian production, and truthfully not very good.
Perry plays Hudson Milbank, a screenwriter. At the movie's start, he smokes a lot of pot which causes something in him to snap. He becomes "de-personalized" which means he always feels detached from his own body. He looks at his hands but they do not feel like his hands.
Kevin Pollak plays Tom, Hudson's screenwriting partner. In the partnership Hudson is the salesman and Tom is the talent. Tom acts as an advisor to Hudson and a sounding board for his insecurities. The two are in the midst of trying to sell a script.
At a pitch meeting for the script, Hudson meets Sarah (Lynn Collins). They instantly hit it off; she is attracted to him despite, or perhaps because of, his insecurities. He sees her as the perfect woman because she is free-spirited and unafraid of things.
Because of the budding romance, Hudson becomes desperate for a cure. He tries various medications and therapists. At first, Sarah deals with his condition and tries to help him get over it. As the relationship goes on it becomes more and more of a problem.
The rest of the story follows Hudson through the ups and down of his romance with Sarah and his struggles with the disease. The movie presents the disease as a jumping off point for many wacky situations and amusing back-and-forth. One wacky situation has Hudson sleeping with one of his therapists, Dr. Blaine (Mary Steenburgen). It turns out she is even more desperate and messed up than he is. In one amusing bit of dialogue, Hudson tells Sarah she looks like a lion, and she tells him he looks like an owl. The jokes are very much hit or miss.