House, M.D.'s Season 7 was, in many ways, an experiment. Putting characters together in a sexual relationship is always tricky on a TV series, and giving House (Hugh Laurie) a taste of what it means to be happy and loved is likewise a bit risky to do on a show where, as the central character, he is a fundamentally unhappy and troubled soul.
Cuddy tells House she loves him, and he follows. It’s probably been so long since anyone has told him that, and it's been so long since he’s desired her, that all rationality flies out the window as he gladly follows her, despite her obvious ambivalence, and his fleeting recognition of it.
House ignores his internal warning system, expressed to Cuddy in the season premiere, and lets his guard completely down in many ways. And when it ends—when he ultimately cannot meet her ever-changing standard of acceptable behavior, he is crushed. His anger, directed inward until the final scene of the season is both at himself and at Cuddy. And to a lesser degree at Wilson for encouraging him.
Wilson may have done House a great service in the long run to have warned Cuddy, as he had Cameron back in Season 1 not to get involved with House if she had the least doubt. "If he opens up and gets hurt, there may not be a next time." It's a dire warning about House's fragility that Wilson gives Cameron in "Love Hurts."
Througought their Season 7 relationship, House is driven by fear; Cuddy by ambivalence. They’re each waiting for the other shoe to drop. Cuddy is waiting for House to disappoint her; House is waiting for Cuddy to realize what a big mistake she’s made by hooking up with him. It’s a disaster waiting to happen.
Cuddy’s basic understanding of House seemed to have fled, and she is unable to separate their professional and personal relationships, however she might try. She seems too often betrayed and disappointed by House’s professional actions, despite his reminders that his actions as “boyfriend” have to be considered differently than his professional behavior. Her disapproval is more strident.
But what we also get is House often being more obnoxious than usual with patients—and with his team. He is less engaged with the medicine far too often. He’s also too often the idiot in the room, and too infrequently the troubled genius, deep in thought and thoroughly involved on some level with curing the patient. Obviously this ramps up once he begins his descent into hell after the breakup, but he’s much less sympathetic in general—except in the realm of his relationship. Perhaps they're both overcompensating.