In 2008 John Cusack voiced the lead role in the animated film Igor. The film takes a new look at the classic sidekick and puts a unique spin on the character.
Igor isn’t just one person, Igor is the designation given to a lowly scientist’s assistant, of which there are many in this film. Cusack’s Igor longs to rise above his station and win the Evil Science Fair. However it’s illegal for sidekicks to do any experiments; they’re only allowed to assist their master. That’s hasn’t stopped Igor from doing experiments in secret and in fact he has created two sidekicks of his own.
Scamper is a rabbit who has suicidal tendencies and attempts suicide repeatedly; however Igor made Scamper immortal so his attempts are all for naught. Scamper is perfectly voiced by Steve Buscemi, who knows a bit about playing off-beat characters. Then there’s Brain, voiced by Sean Hayes, who is a brain in a jar. However he’s not that bright. To illustrate that point, Brain wrote "Brian" on his jar in permanent ink that he can’t get off.
After Igor’s boss is killed in an accident, he listens to his creations, hides the scientist’s demise, and begins to create in his place. Eva is his latest creation; however she’s not evil enough for the evil scientists fair, so she’s brought to the “Brain-wash” to become more evil. This is accomplished by having Eva watch violent acts on television. In the next room Brain is getting his brain cleaned; he’s getting impatient with what’s on his TV screen, and he changes Eva’s screen instead through a very funny sequence of events. Her screen changes to Inside The Actor’s Studio with James Lipton and instead of being an evil monster she is now a kind-hearted wannabe actress (although there are some who would argue that’s the same thing).