When a new case comes up and it turns out to have a supernatural angle, Dylan tries to back out of it. But some cases can't be turned away. After Marcus gets killed by a giant zombie, Dylan is forced to dive back into the world he thought he'd left behind.
All the elements are in the story. A Romeo and Juliet romance between a werewolf girl and a vampire boy. A family of werewolves protecting an artifact for centuries. A group of monster hunters threatening to destroy all unnatural creatures. And a vampire leader (Taye Diggs) taking advantage of a power vacuum with no oversight from inside or outside the supernatural community.
It's not the location (New Orleans). It's not the setting, because the world is full of monsters both fun and foul. It has some fun slapstick elements courtesy of Huntington's role. Even the story seems good at first glance. So is it the actors or the director (Kevin Munroe) who are to blame? Either way it should have been much more fun to watch than it turned out to be.
Beyond the movie on the DVD, there are no extras. This is a very bare-bones DVD release for a movie that totally bombed at the box office.
If you really must see Dylan Dog: Dead of Night, I recommend a rental on Red Box. But if you were looking forward to this flick, you might be better off spending some time reading some of the Dresden Files novels from Jim Butcher or re-watching old Buffy the Vampire Slayer episodes.