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The Healthy Skeptic: IGF-1 Is The Performance Enhancing Drug That Everyone Will Want To Get Their Hands On

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As the world has finally caught on to the fact that world-class athletes from all sports have been using steroids and other performance enhancing drugs (PEDs), the athletes themselves have moved on to the next generation of substances.

And they won’t be caught anytime soon.

Bear with me for a minute and I’ll explain. Well, I’ll attempt to explain.

But before I start explaining that, I want to explain this. This article is not an attempt to justify the use of existing PEDs, nor is this a justification for using the next generation of PEDs. This is simply a matter of recognizing that these substances are out there and that people are using them, and will not only continue to use them but will forever seek out new and better substances to use.

This piece represents acknowledgement of a reality. You can be against the use of all forms of PEDs, but this doesn’t mean you can ignore the fact that these substances are being used.

Steroids represent the Stone Age with regards to these drugs and Bill Romanowski, Jason Giambi, Jose Canseco, Gary Sheffield and Barry Bonds and his trainer Greg Anderson are primitive cavemen. The drugs these guys used – even Human Growth Hormone – and the archaic and ham-fisted manner in which these guys used steroids are embarrassing.

The Balco Labs scandal publicized the fact that underground labs – “UG labs” – exist and have the sole purpose of synthesizing drugs that cannot be detected and/or cannot be acquired legitimately.

These labs create “designer steroids” by altering existing compounds so that they won’t be detected, while maintaining their effectiveness. These labs can also synthesize compounds that are no longer – or never were – produced, and can “copy” drugs that are in production but are not available for consumption for a variety of reasons.

The scenario of UG labs is seemingly cutting edge. However, for the most part the drugs that these labs have been producing, especially in the Balco case, are anything but. The building blocks for these designer steroids are steroids that are a product of the aforementioned Stone Age of PEDs.

If steroids are akin to a fire started by banging two rocks together into a pile of dry grass, than the designer steroid – such as THG – is like a cigarette lighter. By comparison, the next generation of performance-enhancing drugs is like harnessing the power of the atom.

And the “next generation” is now. Not in ten years, not in five years, but today. Actually, the next gen probably started a year or two ago. But you catch my drift.

Let’s take a small step back in time to sometime during the mid-to-late 1980s and the world of bodybuilding. Yes, I said bodybuilding.

Now that the East German communist sports apparatus isn’t around to treat their athletes like lab rats, bodybuilding provides the only remaining real “lab” where performance-enhancing drugs are studied. Since the 1950s, the bodybuilding scene has always been where the latest PEDs have been given their workout. Bodybuilders – regardless of their level of success and fame – have always been willing to treat themselves like lab rats in pursuit of “getting huge.”

The knowledge and use of Human Growth Hormone (HGH) reached the masses within the last few years. Today, thanks to a variety of outlets – legit and otherwise – just about anybody can learn about, get a hold of and use HGH. For most people – especially those involved with the concept of “life extension” – HGH is the definition of cutting edge supplementation.

Which brings us back to the bodybuilding world of the ’80s.

In the mid-’80s, bodybuilders were using HGH that was derived from ground up pituitary glands that were harvested from cadavers. Dr. Frankenstein wasn’t grave robbing and brewing up his own brand of this substance; cadaverous pituitaries were the only source of HGH at the time. There were a lot of physical problems that came from using cadaver-based HGH, but that didn’t stop bodybuilders from using it. A few years later HGH was synthesized in a lab, recombinant HGH was born, and the floodgates opened.

The most important lesson that you should learn from this is that over 20 years ago bodybuilders were using HGH before anyone outside of the world of experimental labs had ever heard of it. Twenty years ago! Bodybuilders knew more about what HGH could do for the human body than most legit researchers did.

I’ll beat the dead horse here to make my point.

If these guys who were at the bottom of the athletic totem pole were using this stuff 20 years ago, what are athletes using today?

IGF-1 – Insulin-like Growth Factor – is an extremely experimental drug that represents the next generation in performance enhancing – check that – life extending drugs.

Without getting too detailed – this isn’t a biochem class – IGF-1 is a hormone just like HGH, but IGF-1 is the most important growth factor that the body produces. IGF-1 is much more powerful than HGH.

Currently the license to conduct human trials using IGF-1 is held by biopharmaceutical company Tercica and is limited to the study of children suffering from growth failure due to IGF-1 deficiency.

Even though the human study of IGF-1 is extremely narrow and limited to kids, the fact that this substance has been studied on rats and humans and is in the hands of people in labs means that the genie is out of the bottle.

IGF-1 has been used in lab studies since at least the late 1990s, so many people have had access to this drug for quite a long time. And there are people with tons of money who would love to get their hands on this stuff.

IGF-1 has produced some amazing results in lab rats. Now before you get all over me for talking about success with lab rats, you have to realize that this success with lab rats did lead to the human trials. And the results of the tests with lab rats have been astounding.

The benefits from IGF-1 are so astounding – and offer such promise to humans – that back in 2002, H. Lee Sweeney, Ph.D., Professor and Chairman of Physiology at the University of Pennsylvania and a recognized expert on the subject of the genetic enhancement of skeletal muscle, spoke to the World Anti-Doping Association with regard to the muscle building and regenerating properties of IGF-1.

In 2002, speaking before The President’s Counsel On Bioethics, Dr. Sweeney was of the opinion that the advent of genetically engineered athletes was not imminent and that studies needed to be done in order to determine the safety and long-term effects of IGF-1.

To think that using IGF-1 to build a better athlete is off in the future, and that this hormone won’t be used until human safety studies can be done, is to ignore the history of how these drugs have been used by athletes. Dr. Sweeney’s position is one of wishful thinking. And I mean no offense to the doctor in any way.

Going back to the HGH situation, bodybuilders were using this hormone in the mid-’80s well before people totally understood how and what this drug really could do. To this day there are many unknowns that are associated with the use of HGH, including the debate as to its safety, yet the use of this hormone is widespread in bodybuilding, in real sports, and in the general population.

Here are some of the reasons why IGF-1 will revolutionize the world of performance enhancing substances, and why athletes will risk – are risking – their health to use it.

IGF-1 has been shown to increase the rate and extent of muscle repair after injury and increase the rate of muscle growth from training. And not only are existing muscle fibers repaired quicker, IGF-1 is responsible for hyperplasia, which is an increase in the amount of muscle fibers.

Hyperplasia is the Holy Grail of performance enhancing benefits, and occurs when muscle fibers actually split, therefore creating more muscle fibers. Hypertrophy is simply an increase in the size of the existing muscle cells, and occurs from weight training and from steroid use. Hyperplasia plus hypertrophy equals a new breed of amazing athlete.

But wait, there’s more.

Rats that were given IGF-1 and did nothing were bigger and stronger than rats that weren’t given IGF-1 but exercised. And I’ll bet you guessed that rats that were given IGF-1 and exercised were the biggest, baddest rats in the house. The positive effects of IGF-1 on the rats continued for months after the rats stopped getting the supplemental hormone, whereas the exercising rats immediately lost size and strength as soon as they stopped exercising.

In another study the muscle fibers of 27-month old rats – old age for rats – that were given IGF-1 during middle age, exhibited no deterioration of muscle fibers that indicate the classic and inevitable signs of aging. These rats did not lose any fast twitch muscle fibers – the fibers responsible for power and speed – and had the same speed and power output that they had when they were six months of age.

To quote Dr. Sweeney, “So we were able to conclude that IGF-1 could prevent all of the hallmarks of age-related atrophy and loss of skeletal muscle function in mammalian aging, at least based on the rodent model, and now we’re hoping to pursue this in larger animal models.”

Dr. Sweeney also says that IGF-1 could be used as an instant muscle builder for members of the general population.

And here’s the final and most compelling reason why IGF-1 is being used right now, and why the demand for this hormone will increase exponentially as time goes by: IGF-1 is undetectable by both blood and urine testing. Because IGF-1 can be injected directly into the muscle, it never enters the blood stream. Therefore, a muscle biopsy is the only way to determine if a person has used IGF-1. And the anti-doping forces will never, ever be allowed to take muscle biopsies from athletes.

In a January 18th, 2004 New York Times Magazine cover story by Michael Sokolove, Dr. Sweeney says (page 30) that after presenting his IGF-1 info at an American Society for Cell Biology conference he was contacted by a high school football coach from Pennsylvania who wanted Dr. Sweeney to treat his entire team. Do you think by now world-class athletes – with world-class money – are interested in IGF-1?

Included in this article (page 28) were additional details with regard to the results of studies, in which rodents given IGF-1 before birth and at four weeks of age experienced a 35% increase in strength in targeted muscles, did not lose any size and strength as they aged and did not lose any of these gains when they stopped training.

Later on in the article Dr. Sweeney admits that athletes could already be using IGF-1. Elisabeth Barton, an assistant professor who was involved with Dr. Sweeney’s studies, says that creating a human athlete along the lines of these super mice “is easy.”

She goes on to explain, “It’s a routine method that’s published. Anyone who can clone a gene and work with cells could do it. It’s not a mystery.”

Dr. Sweeney added that there’s no limit to what can be done with IGF-1 and gene therapy with regards to building a better athlete. To make a sprinter faster Sweeney said, “I’d put the whole leg on bypass. I would put (IGF-1) in through the blood. It would be more efficient than injections (directly into the muscle), which you would need a lot of because you’re dealing with large muscles. But this is nothing a vascular surgeon couldn’t do.”

So to recap, IGF-1 provides almost permanent muscle-creating, muscle-repairing, and anti-aging benefits and is totally undetectable. Do you think athletes are chomping at the bit to get their hands on this stuff?

The legitimate scientific world is following the proper protocols with regards to IGF-1, but the underground world is not bound by the same rules. Legitimate science – rightly so – is nowhere near ready to allow “us” to start using this stuff. But this isn’t the point.

The point is that there is a substance out there that scientists are cautiously touting as an instant muscle builder and a fountain of youth, and for some people this is all that they need to hear. These people aren’t going to wait – haven’t waited – for legit science to bless the use of IGF-1 for human consumption before they go out and inject themselves with it. Adverse side affects? Please.

In 2004 the leading experts on the subject admitted that this gene therapy could already be in use, and that the technology and knowledge is such that the process to deliver it isn’t complicated. Two and a half years later this circle of knowledge, and use, is that much larger.

Knowing how HGH was purloined by people who were too impatient to wait for legit science to do it’s thing, bodybuilders and real athletes did what they had to do to get it and use it, danger be damned. There’s no reason to think that the same situation isn’t occurring right now.

Bodybuilding web sites, bulletin boards, and chat rooms are awash with discussions about IGF-1, what it can do, how to use it, and what drugs to stack with it. There’s talk that underground labs are synthesizing IGF-1, HGH, and a host of other substances.

According to Chemical Muscle Enhancement, a well-known underground PED guidebook written by Internet steroid guru L. Rea and available via download or through Amazon, IGF-1 has even been altered to increase its effectiveness, making IGF-1 ten times more potent (pages 134-136 of Chemical Muscle Enhancement). Several websites make reference to this altered form of IGF-1 – known as DES (1-3) IGF-1.

IGF-1 is being synthesized and altered in underground labs and is being sold on the black market. Bodybuilders are using IGF-1 and it is illogical and naive to think that some athletes at the highest level of sport are not using IGF-1 right now. People who you’ve probably never even heard of are using it just as there are well-known athletes who have already benefited from the use of IGF-1.

People did crazy things to get their hands on HGH 20 years ago, did crazy things to get their hands on whatever the next-gen drug was 30 years ago, and it’s no different today.

While in some sense the public has finally caught on to “steroids,” the high-tech, high-minded athletes have moved on, light years ahead of what the public can conceive of and comprehend. “Steroids” is the Model-T Ford; IGF-1 is the USS Enterprise or the Millennium Falcon.

With each advance in the field of PEDs the underground has been responsible for the spread of knowledge and supply of these drugs. Advances in technology and today’s free flow of information have made it possible for underground labs to synthesize, alter, and deliver into the body drugs of all types.

With money, fame, and even a kind of immortality involved, there’s no telling what some people will do. The mindset of the PED user is that IGF-1 can deliver all three of these.

The use of PEDs up until this point has pretty much been a black and white issue, but with this next generation of substances now available the debate will get much more complicated. PEDs are NOT going to be eradicated, their use will become more widespread as the benefits that they provide become more and more attractive to potential users.

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About Sal Marinello

  • Don Q

    I’m 48, and have been working out in one form or another for 33 years. Always a slow gainer, if I gain at all. But I never did HGH or steroids. This summer I read about the good effects of creatine, with little or no side effects. So I tried that and started making modest gains in my lifts. It seens to have gotten me over some sticking points. When I heard about IGF-1, in relation to that football player on the news, I gave that a try, and ordered 30 lozenges from NOW. Place it under your tounge and let it disolve. I honestly didn’t expect much. I am happy to say I was wrong. My numbers (weight/reps) have gone up consistantly on every exercise I do, almost every workout. This is not at all typical for me. All my life I’ve had to work for weeks to get up one rep. I also feel good, with less aches after the workouts. Granted, that my be a placebo effect, but the numbers don’t lie. And no, I don’t overtrain. I am a dedicated follower of the late high intensity advocate Mike Mentzer.

    I am now trying the SWATS spray, but only once a day. If I like the results, I may move to the recommended twice a day.

    One last thing. Cancer doesn’t run in my family, thank God. So I am not really worried about giving any cancer cells a boost. Others with a family history of the Big C may want to consider the risk.

  • T BONE

    i use igf and im bloody massive, i love it.

  • pieter

    i would love to use igf but am afraid of being tested positive for it as a banned substance in rugby!can it be detected and if so for how long after you’ve stopped using!

  • Brunelleschi

    This article may be right on the money regarding IGF-1, but the PED debate overall lacks balance.

    There is nothing wrong with using hormones that occur naturally, IF it’s done with proper medical supervision. Everyone has HGH and testosterone/progesterone in their body. You need them, and a lot of other things, for good health.

    Abusing them is a bad idea-that’s a no brainer. Using them if they are below normal levels is not only safe, it’s smart.

    All this negativity against HGH and test makes about as much sense as attacking skin and teeth.

    There are a lot of very unhealthy people that are missing what they need because of all this negativity, and I’m not talking about just athletes.

    I take several hormones and have my blood checked regularly, and my health went from terrible to excellent in less than a year.

  • Steve

    No one seems to mention that there is a disease associated with excess production of IGF-1. It’s called acromegaly, the result of a pituitary tumor. The excess amounts of IGF that people seemed to believe will build up their bodies has destroyed mine. I have chronic pain, fatigue, depression and most of my joints have been damaged or destroyed. I’m at risk for colon cancer, blindess, heart disease and several other nasty conditions. And you want to buy this stuff? I’d happily give you all of mine beyond my physiological needs. I can’t believe people are paying money to take this stuff. I’m facing surgery and radiation therapy to get rid of mine. I wouldn’t wish what I’ve gone through with IGF on anyone.

  • Frank

    Great forum,interesting subject. Just bought some legal stuff by NOW products, simply labelled IGF-1, Anyone tried this stuff? Comes in a sublingual lozenge 30 to a bottle.

  • Chris
  • Chris

    If you look up IGF-1 on wikipedia and then click on igf and bodybuilding in the links section, you’ll find an article exactly like this one. This one is slightly modified- the equiv of a 3rd grader paraphrasing a newspaper.
    It would be good to address possible cancer risks.. Has anyone tried HexaGHen?

  • I’ve checked out quite alot on IGF-1 and am actually currently on it. The only thing is, I’m not taking pills and I’m not injecting it. I’m burning body fat and I haven’t felt this good in years. Check it out!

  • Jon Wood

    I just watched the Andy Murray quarter final match and it reminded me of why I gave up competitive bodybuilding. Nadals Physiqe is not a normal one. Im not a young man just 40 years of experience in power sport. There is no way you will stop this there is too much money in sport. It saddens me to see someone with heart and talent beaten by 5ml of ……….

  • if you can believe what you read on the body building message boards the IGF-1 Long 3 is where it’s at.

    i find it very interesting that Major League Baseball saw fit to include IGF-1 on its list of banned substances this year despite the fact there isn’t and won’t be any way to test for it.

  • Warren

    So which one is more potent? IGF-1 or IGF-1 Long3? I’ve read about some of the stuff it does and it sounds pretty impressive. Any thoughts?

  • RoseBleue

    This is an interesting article, but as a newly diagnosed acromeglic I am alarmed that the very thing that my body is overproducing (IGF1) is being represented as it is in your article. First of all, it WAS detected by a simple blood test that had nothing to do with extracting muscle tissue. Maybe most alarming of all, acromegaly, the name of the disease that people have whose bodies overproduce IGF1, is reputed to SHORTEN, not LENTHEN your life. In living with the disease, you find that you have many problems – with trapped nerves, such as carpal tunnel syndrome and one of the main muscles to enlarge is your heart. I would urge anyone considering this “option” to read about acromegaly before choosing to take it on deliberately.

  • jackson

    oh jeeze im sorry it was going so slow!

  • don

    this stuff works good but you need to use alot more than whats recomended, which makes it not very cost effective.

  • Sikboy

    I am currently on IGF-1, i have used it before with large quantities of steroids.

    IGF-1 and steroids is teh most potent mucle building stack in existance IMO.

  • nick b

    hmm i know a friend who used igf, he said while he was on it hilucinated spiders attacking him 2-3 times a week.

  • sal m

    researchers at the jonas salk school of medicine at johns hopkins university and at the mayo medical center in minnesota have been studying the affects of igf-1 in studies on mice.

    perhaps you can look into the possibility that they are involved in any human trials.

    also, body builders don’t get perscriptions for the igf-1 they use…

  • glenn m.

    My Mom has ALS and since this disease is debilitating and fatal, I think she might benefit from IGF-1, despite the risks. The problem is finding a doctor to prescribe this. Anybody….?

  • sal m

    there is no question that igf-1 – like most other drugs/substances – can pose serious health risks if either used or abused. however, those playing the performance enhancing game have never been concerned with the potential downside associated with any of these substances.

    to the point that there are no proven performance benefits from using igf-1 is almost irrelevant for two reasons. the first being that once the word is out that a substance has purported benefits and there are those willing to attest to these benefits, others will sieze upon this as “proof” enough to use the substance. the second issue deals with the fact that legit science will never study the illegit use of substances for the sole purpose of performance enhancement.

    there really aren’t any definitive studies dealing with the efficacy of steroids with regard to performance enhancement, yet there are countless example of anecdotal success stories. the reasons for this situation are many, but the most important reason is that science will never be able to study these substances in the way that those looking for an edge will use them.

    this post isn’t meant to champion the use of these substances, but to recognize the fact that people are willing to go to extraordinary lengths to get an edge.

  • frank R.

    Even having slightly higher levels of igf-1 can more than double your risk of cancer, i cant immagine what pumping your body full of it will do. So for me, the short term side-effects dont compensate for the negative long-term effects.

  • frank R.

    here we go, the negative side-effects, everything has a catch to it.

  • frank R.

    Yeah lets all go use this and 10 years later die of cancer!

  • After use of scitopin and sazann hgh i found neither had any great benifits.I stumbled across igf1 by accident from a friend who bought it but was’nt sure whether to use it or not so i bought it. After using just 1 bottle i noticed the gains dramatically this was so unbeleivable because i had been suffering from fatuge as well as low sex drive and even my eye sight was starting to become a bit how u doing, then this wonder drug ” fountain of youth ” was here just couldnt beleive how good it has been it has cut my body fat down and increased my muscle development bigger then it has ever been even more then doing a cycle of test. My biggest problem now is were to get more.Im so happy with igf1 and i think with using in moderation it can help so many other people so to all those guy’s that use test this is the way to go no more low sex drive after a course no more mood swings and no more water retention just perfect lean muscle mass i hope that it works ass well for u as it has for me.matt h.

  • sal m

    first of all anyone who makes a reference to the Schipperke is worth listening to!

    there really isn’t a place for rational thought when discussing why athletes or people in general will use supplements or other PEDs. i agree with you when you say that you wouldn’t expose yourself to the potential havoc that igf-1 or any other substance could have on your system.

    but the bottom line is that igf-1 has been shown to be beneficial in the area of regrowing certain connective tissues. i spoke with a researcher who worked on studies where ligaments and tendons were regrown in horses who was of the opinion that igf-1 would definitely do the same in humans.

    so were not just taking about getting bigger here, we’re talking about being able to make connective tissue stronger, and also being able to heal people quicker and better than before.

    also, whether or not there is enough science to justify these conclusions or to allow this substance to be used in humans isn’t the issue. the issue is that in some quarters the thought is that this stuff DOES work and CAN do miraculous things. for some people this is all they need to hear.

  • Glen G.

    I don’t come from a background that allows for very hospitable thoughts regarding supplements, and most of my encounters with IGF-1 have been in the framework of macronutrient ratios in the diet, their effects on IGF-1 production in the body, and subsequent health effects. While I’ve read varying reports about what in the diet causes the greatest surge in IGF-1 (carbohydrates versus protein), I’ve seen precious little evidence showing that high IGF-1 levels are beneficial, and that they are antiapoptotic and contribute to tumor growth.

    It’s amusing that they use rodent studies to claim that IGF-1 actually extends lifespan, because from what I’ve seen, a strain of mice who have had the gene that codes for IGF-1 production knocked out of them have reliably managed to outlive their IGF-normal brethren by a good quarter of a lifespan or more. These IGF-1 deficient mice were also dwarfs. This correlates pretty well to the slew of evidence suggesting that large people in general are more susceptible to all sorts of diseases. Bulking up and living long tend to be two diametrically opposed things in the natural kingdom, at least when it comes to members in the same species. This is intuitive: who do you expect to live longer, a Schipperke or an Irish Wolfhound? Why do we then jump on the supplement bandwagon whenever some chemical is discovered that will make us HUGE, justifying our hysteria with claims that being big and meaty is the secret to longevity?

    I’ve also read a little evidence suggesting that those same IGF-1 deficient mice also lacked in the brains department, and that for all the terrible things IGF-1 seems to be contribute to, it does appear to be neuroprotective, at least in doses that one would find in a normal body under normal dietary conditions. But I can’t see anything good enough about this chemical to justify putting myself through the rigors of uncontrolled cell growth and subsequent tumorigenesis that would inevitably follow from high doses of it.

  • sal m

    i always find it – shall we say interesting – when in any sport muscularity increases to a great degree.

    go back and watch an nba game from the mid 90s on espn classic and you’ll be amazed at the difference in size of the players. those guys from 10-15 years ago look like kids compared to the kids who are playing in the pros today.

    and guys were weight training back then so the increase in size can’t be attributed to any training related variable. there haven’t been any earth-shattering breakthroughs in the conditioning field that could be responsible for such an amazing transformation.

  • jordan

    great artical lots of info thanks. you didnt really touch on basketball i would bet alot of them are using so many of them seem like freaks of nature i mean just look at lebron james 20years old and he looks like a monster and all these guys going threw knee surgeries and coming back and playing better than before.

  • sal m

    i don’t watch much tennis, but i recently saw nadal in action and was surprised at how muscular his upper body appeared.

    you make a great point with regards to the near impossibility for a person to develop and maintain muscle mass while competeing, and how the public is largely unaware of this.

    this was one of the things that had me suspicious about baseball players 10 or so years ago…there were way too many older guys putting on and keeping noticable amounts of muscle mass.

  • Alex

    I am sure Rafael Nadal and other tennis players like Roger Federer (he is not as weak as he looks) are using the drug IGF-1 (or others), with a mixture of other non detectable agents. I work in the gym like crazy and I can tell you that there is no way you can build up and upkeep these muscles naturally when you are playing tennis tournaments every week around the world (how many calories do you lose in a match that is 5 hours?) If the mass public were educated in professional sport they would not bother athletes and just let them be, knowing everybody uses something. The people that question athletes should take the same drugs they do and go try playing like them. Great article, please write more!!!!!!!

  • sal m

    this is a murky area…there are very narrow applications for the use of igf-1 in humans, as i mentioned.

    how people get their hands on this stuff is conjecture, but you can be sure that since everybody has their price, this stuff can be had.

    have you been wondering why guys seem to be recovering so quickly from major surgeries? knee reconstructions, tommy john surgery, other ligament and tendon surgeries?

    without naming names, i’ll bet that you can think of at least three prominent athletes who have gotten ready very quickly after one of these surgeries. grimsley himself reportedly came back from his surgery very quickly.

    i’m working on a piece that covers this exact topic and hope to have it ready for this week.


  • Pete W.

    Great article, Sal. Just superbly well-written and balanced. As a big baseball fan, I’m very concerned about the use of PEDs by players. I wouldn’t be surprised if there were a handful of them using IGF-1, though I doubt it’s widespread. It seems that currently, the availability of IGF-1 is quite limited. Am I right? I mean, can anyone just go on the internet and buy it? Are there many doctors/clinics dispensing it right now for sports performance? It would be great if you can write more about this topic in the future, updating us about its actual availability and use by bodybuilders/athletes.

  • Outstanding analysis, Sal. Indeed, besides erstwhile bodybuilders, Olympic athletes were documented to have been using HGH by 1980 (steroid testing was implemented at the 1976 Games) and designer steroids by 1984. By 1988, apparently, at least some were already enjoying the efficacy of IGF-1 for performance enhancement. In football, meanwhile, NFL and NCAA players were well acquainted with HGH and low-dose testosterone by 1990, when both organizations began trumpeting “year-round” random urinalysis as THE solution to muscle doping. Unfortunately, such organizers were wrong. Size and performance parameters have only risen since, and today we still lack any bona fide prevention. As a former small-college football player who used steroids long ago (1982) and, most significantly, as a researcher/writer on the topic, I fear my children’s competing in sport at higher levels. My wife, a former All-American gymnast, feels the same. And that’s a shame.

  • Calif

    Among subjects who were physically active, an increase in IGFBP-3 was associated with a 48 percent reduction in colon cancer-specific deaths. No association was apparent for IGF-1.

    For the physically inactive, there was no association between IGF-1 or IGFBP-3 and colon cancer survival.

    Haydon told Reuters Health that that “physical activity can increase IGFBP-3 levels, which, in turn, reduces the amount of free IGF-1.” IGF-1 has been shown to stimulate cell growth, inhibit cell death, and promote angiogenesis — the formation of new blood vessels, which tumors need to grow.

    Reuters 29 May

    Go to: http://www.go-iplex.com for as save IGF1/IGFBP3 product.

  • sal m

    if more companines are working with igf-1 that just increases the chances for others to get their hands on it, and start using if in what ever manner that the wish.

  • David

    I’m gonna get a huge bottle of it and mix it with my milkshakes! Yummmmmm! Muscles!

  • sal m

    i used the pictures of body builders because they represent the freakish side of what these drugs can do. however, the potential anti-aging and muscle repairing benefits of igf-1 will thrust this drug into the mainstream.

    modafinil/provigil – which was cocktailed into the mix by balco – is an anti-narcolepsy drug, and is a stimulant.

    the anecdotal stories provided as a result of the balco case speak to this drug’s ability to crank athletes up to incredible levels if intensity in both their workouts and in competition.

  • I don’t have much interest in this type of physical performance enhancing drug but I’d love to read some informed stuff on mental PEDs like modafinil…

    Frankly I’d be too embarrassed to go out in public if I looked like the freaks you have pictured here, Sal, but if I could do the same for my brain, it might be different!

  • sal m

    IGF-1 seems to be the closest thing to a super serum that we’ve seen up until this time…if in fact IGF-1 proves to be safe, people from all walks of life will be lining up for it, and it could put a huge dent in the business of cosmetic surgeons…as a matter of fact, as long as it’s available, safety won’t matter that much to many people.

  • Wonder how long until the military uses drugs like these to produce “super” soldiers.

    Wasn’t that the origin story for Captain America? Secret military performance enhancing drugs? I can remember when only the “serious” science fiction eventually became reality. Now it seems even the comic book version of science fiction is destined to become reality.