Personally, I found CINEMA 4D R13 very easy to use and straight forward in its layout. It can take a little bit to get the hang of modeling items and making more complex shapes – especially if you are new to 3D, but with the help MAXON's Cineversity training subscription and a little bit of time, you can get on your way pretty quickly.
You can download a demo, or purchase the CINEMA 4D R13 Studio product for $3695.00 USD. There are also other levels of CINEMA 4D R13 available as well starting off at $995.00 USD. These include Prime, Broadcast, and Visualize. To see what each version contains you can check out their feature comparison sheet.
If you are wanting to get into the creation of professional 3D graphics with a system that will give you everything you need to create advanced graphics for film, animation, games, or just about anything else that you might want to create for, then I highly recommend this product.