It's a beautiful thing. It's simple and it's frustratingly complex all at the same time.
Until I have another 900 hours to dive deep into all of those customization options, however, I keep my own settings sweet and simple. Omnifocus allow me to bridge the divide between work and home and all of the various things I need to get done between them. I create individual "projects" where I list out the steps I need to take, attach any materials/notes that will help me along the way, and tag them by context so that I can easily see "what" is for "when" and "where."
At the moment it's kept me straight on what goes where as I'm working on two magazine covers, a full layout on a health and wellness special section, tracking every individual ad that runs in multiple magazines and their state of preparedness, keeping track of each individual page as it is either exported to the printer or emailed to an outside printing firm, tracking progress on a grocery store circular for the approaching holiday, converting our monthly magazine into an online flipbook that...well, I'm sure you get the picture.
The fact that I know what the key things are in my workload, and I know their immediacy and (with a quick check of my materials) what shape each is in as regards to their completion is a lifesaver and is why i wholeheartedly think that Omnifocus has more than lived up to what I hoped to achieve with its help.
Gone are my hesitations over pricing and in their place is a sense of gratitude and a willingness to let everyone know that if you are looking for a way to bring an ever increasing work and responsibility load into focus...you could search for quite a while to find anything even close to the answer that Omnifocus was for me in that situation.
Omnifocus is also available as a desktop application as well as mobile applications for the iPhone. It also provides, via a proprietary sync option, access to their OmniSync server that allows you to tie your information all together and have everything at your fingertips as needed. One caveat to the entire system is that it is based to run in an Apple world...all of it. The desktop, mobile phone, and ipad apps are all geared towards running on apple's OS and (as of yet) there doesn't seem to be any plan to cross-platform it over to Windows.