Although some consumer advocacy groups have supported the bill, groups which represent the interests of small farmers like The Farm to Consumer Legal Defense Fund have opposed it vehemently. As finally passed, some aspects of the bill seem to have been made more reasonable, with most farms and cattle ranches are exempted from the worst regulatory provisions, but the harsh enforcement measures and extreme emergency powers for the FDA remain intact.
Putting aside the harm the bill will certainly still do to a lot of small businesses, what concerns me the most and what I consider more than sufficient reason to see this bill strongly opposed in the Senate, are the clearly unconstitutional powers which it gives to an agency which already has far too little citizen or congressional oversight. With the FDA's history of scandals and undue influence from the pharmaceutical industry, giving it more power and authority over everything we eat just seems like an inherently bad idea. Despite scaremongering in the media, the actual number and severity of outbreaks of food related illness remains remarkably low and the current level of regulation from state agencies and the USDA seems to be entirely adequate. What this bill mostly does is protect the food industry from competition, empower bureaucrats and trample on citizens rights. There's no reasonable justification for enacting it into law.