Getting online with Dr. Mario isn't much of a pain at all. You can only do it through the Dr. Mario portion, but the set-up is pretty similar to that of Super Smash Bros. Brawl. Except with a much, much better connection. But here's where things get even better: you can play against friends online with only one of you having a copy, exactly like the DS Download play service. It's not only a wonderful marketing scheme to introduce more people to the game, but it's something I hope more WiiWare games include in the future. Believe it or not, the DS version of this has swayed me to pick up some games I would have otherwise skipped. Offline play is two players only.
If you're looking for something bad about Dr. Mario Online Rx, I can say with clarity that you might be looking for a while. Sure, I'm sure you can nitpick if you want, but there's not much of a point to it. It might not break ground with the Wii like other WiiWare titles do, but with Dr. Mario Online Rx, you get a balanced game that every gamer of every age and skill level can enjoy without problem.
Pros: Visual makeover is minimal, but welcome. Online play is great. Reasonably priced. Accessible for hardcore and casual gamers alike.
Cons: None, really.
Dr. Mario Online Rx is rated E (Everyone) by the ESRB.
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