Me Talk Pretty One Day by David Sedaris is his account of his life from the time when he was a child with a lisp (which apparently in some way pre-destined his homosexuality) up to his life as an adult. He mostly chronicles his relationship with his parents, siblings, and lovers.
Mr. Sedaris is hilarious in what feels like a "caffeinated" string of jokes he delivers throughout the book that had me laughing out loud nearly every third or fourth page. In the early part of the book, he fights his need to deal with his lisp head on while working with a speech therapist by avoiding the letter "s" when speaking. So, for example, when his speech therapist asks what he plans to do on New Year's Eve, the character responds "On the final day of the year we take down the pine tree in our living room and eat marine life."
That's pretty clever and funny stuff. The book really hits it stride, for my money, when he gets older and goes through a series of odd jobs and even odder relationships (in and out of the workplace). At one point he is working for a moving company in New York. He goes into a hilarious riff discussing how rent determines break-ups in some way and that often times during break-ups folks are itching to tell all the details.
When describing one interaction where a man found out that his significant other was having sex with her ex-boyfriend on their couch, they would ask how many times. The broken man responded (yelling because they were in a truck):
"Just once that I know of, but isn't that enough?"
"It depends, how much was your rent?"
It's silly and the humor is a bit obvious at times but that's what made the book so enjoyable. Whether it was his much younger brother who, like Denis Farina in Get Shorty, carpet f-bombed like it was going out of style or his hilarious interactions with French people as he was learning French, he always has a silly slant on already funny situations.
He was insightful at times, including lamenting the lost distinction between a phobia and a loathing. But he's at his best when he is honest and biting in his writing. The high point of the novel was when he writes about the experience of taking French from a very angry woman who taught a group of frightened non-French speakers.