Wilson is suspicious of the coffee offering from the man who constantly begs, borrows, and steals food and beverages from him. "Because it's either that or I accept the fact that you've done something nice, and then I have to deal with the horsemen, and the rain of fire, and the end of days," Wilson explains.

So House and Wilson play a little Vizzini and Wesley, and Wilson takes the cup that was not offered to him. Did House predict he'd do that, or did he lace them both? I'm inclined to think it doesn't take a genius to think Wilson would not take the proffered cup, but I have no idea how someone would act on the combination of anti-depressants, Vicodin, and amphetamines.

Because, as House deduces later, Wilson has been dosing him, too. Scary how alike they are, underneath all that unalikeness. Wilson's experiment is testing if House is happier on anti-depressants, proof that he's depressed. I hope Wilson knows how anti-depressants would interact with Vicodin, amphetamines, alcohol, and god knows what else House puts in his system, because otherwise he's quite the hypocrite for complaining about how dangerous House's experiment is.

What amphetamines do to Wilson is make him jittery and talk a mile a minute. His pep talk to Foreman is less effective than entertaining, and he conducts a highly inappropriate breast exam on a confused patient. Finally Wilson realizes something's not quite right: "I feel like my heart's going to explode." Don't say that, Wilson. Not in this episode of the exploding head. "Excuse me, I have to go kill someone."

The fact that Wilson still yawns on speed is House's proof that the oncologist is on anti-depressants, and he berates him for keeping it a secret. Mid-rant, Wilson cuts him off with: "This is why I take them," but House has the best retort: "They're antidepressants, not anti-annoyance-ants." House implies Wilson's a hypocrite for not mentioning them while lecturing House on how to fix his own life.

"You wouldn't take them," Wilson protests. "You'd rather OD on Vicodin or stick electrodes in your head because you could say you did it to get high. The only reason to take anti-depressants is that you're depressed. You have to admit you're depressed."

It's the line I've been waiting for since "Half-Wit" – some implicit acknowledgment that the buried motivation for House faking brain cancer was something other than getting high, that it was the act not just of an out of control drug addict, but of man desperate for, but unwilling to admit a need for, help.