Foreman tells his colleagues that he's submitted his resignation, but he won't tell them why. Chase, emulating House a little himself, chooses to turn that into a mystery, and is determined to deduce why neither Foreman nor House will reveal the reason, and why Foreman has, for the first time in recorded history, laughed at one of House's jokes – and a lame one at that. Though "most of your jokes are excellent" Chase brown noses, proving that he's in no real danger of turning into House.

His conclusion is that Foreman and House are ashamed of Foreman's reasons for leaving, and that Foreman really doesn't want to go. Shame and pride have been hot topics lately, and the obvious answer to why House won't ask Foreman to stay is that he's too proud. But if he'd watched the episode, Chase would probably agree that that's not all the evidence suggests.

House seems resigned to the fact that he's going to lose Foreman, and the resignation seems to come from agreement with the reasons for it – that he's in danger of turning into House, and that's not necessarily a desirable trait. After accepting Wilson's latest coffee offering and questioning his seemingly innocent yawn as a symptom, House has an almost-poignant exchange with his friend: 

Wilson: You don't want to end up like you. ... You could try bargaining with him. Give him a raise.

House: How much do you think it would cost to make him want to be like me?

Cuddy admonishes him for not making the effort to keep the neurologist. "Have you talked to Foreman yet? You haven't. Because then you'd have to confront your own emotions." House: "Is bile an emotion?"

Instead of focusing on that losing battle, fraught with emotion and all that scary stuff, House turns his attention to the medical mystery. Continuing the recurrence of infections plaguing (but not literally) Foreman, whose misdiagnosis of one killed a patient two episodes ago, House believes Addie has an atypical infection. He persists in that diagnosis despite all evidence to the contrary.

He also bounces around with his camcorder, gets giddy at the prospect of his patient's impending heart attack, shows even more traces of Hugh Laurie's rubber-faced comedic past, and overall seems oddly peppy for a guy continuously proven wrong, or at least not proven right.

Until he is proven right, just not in the way he thought. He's also proven right about Wilson and his yawning as a medical symptom. We see House get amphetamines from the pharmacy for no particular reason – but then does House need a reason to illegally procure drugs? – and then sit at his desk with two cups of coffee and an evil grin.