A woman runs across the Brooklyn Bridge, followed by a man. As he enters the frame, one can see rope over his shoulder. Rappelling gear is pulled out of a backpack. The two strip to their underwear, and they hook into a bungee cord. They see a man who calls to them, in need of help. When they come up, they see his bloody fingers. Time to call in the cops.

Det. Mac Taylor (Gary Sinise) is enjoying the company of a female companion when his cell phone goes off. Not long afterwards, her phone goes off. This will be a busy night for both.

Across town, Det. Stella Bonasera (Melina Kanakaredes) is taking charge of the case until Taylor arrives. She is joined by Det. Don Flack (Eddie Cahill), back on the job after being caught in a bomb explosion ("Charge of This Post"). The victim is a man named Sam McFarland. Det. Lindsay Monroe (Anna Belknap) asks Flack how many phone numbers he got from his admirers. Three, he says.

A search for evidence uncovers lipstick on the man's cheek along with an engagement ring found on the bridge itself. Could this be a case of a woman scorned?

In the midst of all this, Dr. Peyton Driscoll (Claire Forlani) from the medical examiner's department shows up. Who is she? The same woman who Mac slept with hours before. Evidently, he has moved on from his wife's death on 9/11 enough to become romantically involved again. This should get interesting....

In the meantime, Det. Danny Messer (Carmine Giovinazzo) and Dr. Sheldon Hawkes (Harper Hill) investigate another death. When they peer over the apartment balcony, Det. Jessica Angell (Emmanuelle Vangier), already on the scene. looks up to see them and proves she is more than capable of handling Messer's smart mouth. Hawkes questions the woman who found the victim, and death had already occurred when SHE got there. Hawkes tells her he needs her fingerprints to eliminate them from those collected at the scene.

Mac and Flack talk to the girlfriend of their victim. She is with her father (Michael Nouri), who is overprotective. Mac suggests they might do better if left alone. This does not make Dad happy, but he leaves. She hadn't seen Sam that evening, and wasn't planning to. Mac asks her how long since she quit smoking, noticing the patch on her arm. She says it is to treat a spider bite. While the cops may not believe her, they cannot make an arrest without proof.